Drug interactions
Daridorexant + Methadone
Severity: Moderate
Daridorexant and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining methadone with daridorexant adds CNS depression, which can worsen sedation, next-day impairment and psychomotor performance. Respiratory depression is a concern at higher doses or in vulnerable patients.
What this interaction means in plain words
Daridorexant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression from opioid agonism and orexin receptor antagonism.
What to do
Use the lowest effective daridorexant dose and monitor for excessive sedation and respiratory depression. Advise patients to avoid driving or hazardous tasks if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Methadone?
MediHelp rates the interaction as moderate. Daridorexant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining methadone with daridorexant adds CNS depression, which can worsen sedation, next-day impairment and psychomotor performance. Respiratory depression is a concern at higher doses or in vulnerable patients.
How serious is the interaction between Daridorexant and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and monitor for excessive sedation and respiratory depression. Advise patients to avoid driving or hazardous tasks if drowsy.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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