Drug interactions
Daridorexant + Netupitant-palonosetron
Severity: Moderate
Daridorexant and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may increase daridorexant exposure and next-day somnolence or impaired alertness. Labeling limits the daridorexant dose with moderate CYP3A4 inhibitors.
What this interaction means in plain words
Daridorexant and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant, a moderate CYP3A4 inhibitor, decreases the CYP3A4-mediated clearance of daridorexant.
What to do
Limit daridorexant to 25 mg per night when a moderate CYP3A4 inhibitor is used. Counsel the patient about daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Daridorexant and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant may increase daridorexant exposure and next-day somnolence or impaired alertness. Labeling limits the daridorexant dose with moderate CYP3A4 inhibitors.
How serious is the interaction between Daridorexant and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg per night when a moderate CYP3A4 inhibitor is used. Counsel the patient about daytime drowsiness and driving.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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