Drug interactions
Daridorexant + Oxcarbazepine
Severity: Moderate
Daridorexant and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and together they may worsen next-day drowsiness and impair psychomotor performance. Oxcarbazepine may also reduce daridorexant levels through CYP3A4 induction, which could blunt its hypnotic effect.
What this interaction means in plain words
Daridorexant and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus weak to moderate CYP3A4 induction by oxcarbazepine lowering daridorexant exposure.
What to do
Counsel patients on daytime impairment and driving risk. Reassess daridorexant efficacy, since labeling advises avoiding use with moderate CYP3A4 inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Oxcarbazepine?
MediHelp rates the interaction as moderate. Daridorexant and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and together they may worsen next-day drowsiness and impair psychomotor performance. Oxcarbazepine may also reduce daridorexant levels through CYP3A4 induction, which could blunt its hypnotic effect.
How serious is the interaction between Daridorexant and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on daytime impairment and driving risk. Reassess daridorexant efficacy, since labeling advises avoiding use with moderate CYP3A4 inducers.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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