Drug interactions
Daridorexant + Promethazine
Severity: Moderate
Daridorexant and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase next-day drowsiness and impair psychomotor performance and driving ability. The risk is greater at higher doses and in older adults.
What this interaction means in plain words
Daridorexant and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive CNS depression from histamine H1 antagonism and orexin receptor antagonism.
What to do
Avoid combining where possible; if needed, use the lowest effective doses and counsel patients about daytime impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Promethazine?
MediHelp rates the interaction as moderate. Daridorexant and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase next-day drowsiness and impair psychomotor performance and driving ability. The risk is greater at higher doses and in older adults.
How serious is the interaction between Daridorexant and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, use the lowest effective doses and counsel patients about daytime impairment and driving.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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