Drug interactions
Daridorexant + Selegiline
Severity: Moderate
Daridorexant and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both may cause sedation, and combined use could add to psychomotor impairment and daytime drowsiness. The risk is greater in older patients.
What this interaction means in plain words
Daridorexant and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective daridorexant dose and counsel about driving and daytime impairment. Reassess if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Selegiline?
MediHelp rates the interaction as moderate. Daridorexant and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both may cause sedation, and combined use could add to psychomotor impairment and daytime drowsiness. The risk is greater in older patients.
How serious is the interaction between Daridorexant and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel about driving and daytime impairment. Reassess if excessive sedation occurs.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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