Drug interactions
Darifenacin + Digoxin
Severity: Moderate
Darifenacin and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In pharmacokinetic studies, darifenacin produced a small rise in digoxin exposure. Digoxin has a narrow therapeutic index, so even small increases may matter in some patients.
What this interaction means in plain words
Darifenacin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Digoxin belongs to Cardiovascular.
Why it happens
Possible inhibition of P-glycoprotein-mediated digoxin transport; the mechanism is not firmly established.
What to do
Monitor serum digoxin concentrations and for signs of toxicity when starting or stopping darifenacin. Adjust the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Darifenacin with Digoxin?
MediHelp rates the interaction as moderate. Darifenacin and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. In pharmacokinetic studies, darifenacin produced a small rise in digoxin exposure. Digoxin has a narrow therapeutic index, so even small increases may matter in some patients.
How serious is the interaction between Darifenacin and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and for signs of toxicity when starting or stopping darifenacin. Adjust the digoxin dose if needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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