Drug interactions
Darifenacin + Ergotamine
Severity: Minor
Darifenacin and Ergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is not a significant CYP3A4 inhibitor, so a meaningful rise in ergotamine levels is not expected. The legacy concern about ergotism is unsupported for this pair.
What this interaction means in plain words
Darifenacin and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Ergotamine belongs to Central Nervous System.
Why it happens
No established mechanism, as darifenacin has no clinically relevant CYP3A4 inhibition.
What to do
No specific action is needed beyond usual monitoring for ergotamine toxicity. Avoid ergotamine with true strong CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Darifenacin with Ergotamine?
MediHelp rates the interaction as minor. Darifenacin and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is not a significant CYP3A4 inhibitor, so a meaningful rise in ergotamine levels is not expected. The legacy concern about ergotism is unsupported for this pair.
How serious is the interaction between Darifenacin and Ergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond usual monitoring for ergotamine toxicity. Avoid ergotamine with true strong CYP3A4 inhibitors.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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