Drug interactions
Darifenacin + Fedratinib
Severity: Moderate
Darifenacin and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise darifenacin exposure. This increases the risk of anticholinergic adverse effects.
What this interaction means in plain words
Darifenacin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4 (and CYP2D6), reducing darifenacin clearance.
What to do
Monitor for anticholinergic effects and reduce the darifenacin dose if they occur, keeping it at 7.5 mg daily or less if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Darifenacin with Fedratinib?
MediHelp rates the interaction as moderate. Darifenacin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise darifenacin exposure. This increases the risk of anticholinergic adverse effects.
How serious is the interaction between Darifenacin and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the darifenacin dose if they occur, keeping it at 7.5 mg daily or less if needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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