Drug interactions
Darifenacin + Hyoscyamine
Severity: Moderate
Darifenacin and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinic, so combining them intensifies dry mouth, constipation, urinary retention, blurred vision and tachycardia. Confusion may occur in older adults.
What this interaction means in plain words
Darifenacin and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Darifenacin with Hyoscyamine?
MediHelp rates the interaction as moderate. Darifenacin and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinic, so combining them intensifies dry mouth, constipation, urinary retention, blurred vision and tachycardia. Confusion may occur in older adults.
How serious is the interaction between Darifenacin and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy where possible; otherwise monitor for anticholinergic toxicity and reduce dose if it occurs.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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