Drug interactions
Darifenacin + Lopinavir
Severity: Major
Darifenacin and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, is a potent CYP3A4 inhibitor and can markedly increase darifenacin concentrations. This raises the risk of anticholinergic toxicity.
What this interaction means in plain words
Darifenacin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darifenacin belongs to Genitourinary; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted lopinavir strongly inhibits CYP3A4 metabolism of darifenacin.
What to do
Avoid if possible; otherwise limit darifenacin to 7.5 mg daily and monitor for anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Darifenacin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Darifenacin with Lopinavir?
MediHelp rates the interaction as major. Darifenacin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir, boosted with ritonavir, is a potent CYP3A4 inhibitor and can markedly increase darifenacin concentrations. This raises the risk of anticholinergic toxicity.
How serious is the interaction between Darifenacin and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise limit darifenacin to 7.5 mg daily and monitor for anticholinergic toxicity.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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