Drug interactions
Cisapride + Lopinavir
Severity: Contraindicated
Cisapride and Lopinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir boosted with ritonavir strongly inhibits CYP3A4, which is the main pathway clearing cisapride. Raised cisapride levels can cause serious QT prolongation and torsades de pointes.
What this interaction means in plain words
Cisapride and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Lopinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated cisapride metabolism by the ritonavir component, with lopinavir's own QT effect.
What to do
Do not coadminister; use an alternative prokinetic in patients on lopinavir/ritonavir.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
Frequently asked questions
Can I take Cisapride with Lopinavir?
MediHelp rates the interaction as contraindicated. Cisapride and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir boosted with ritonavir strongly inhibits CYP3A4, which is the main pathway clearing cisapride. Raised cisapride levels can cause serious QT prolongation and torsades de pointes.
How serious is the interaction between Cisapride and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative prokinetic in patients on lopinavir/ritonavir.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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