Drug interactions
Avanafil + Lopinavir
Severity: Contraindicated
Avanafil and Lopinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is co-formulated with ritonavir, inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual changes and priapism.
What this interaction means in plain words
Avanafil and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition decreases avanafil metabolism.
What to do
Avoid avanafil with lopinavir/ritonavir; choose a different erectile dysfunction option.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
Frequently asked questions
Can I take Avanafil with Lopinavir?
MediHelp rates the interaction as contraindicated. Avanafil and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir, which is co-formulated with ritonavir, inhibits CYP3A4 and substantially raises avanafil exposure. This increases the risk of severe hypotension, syncope, visual changes and priapism.
How serious is the interaction between Avanafil and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid avanafil with lopinavir/ritonavir; choose a different erectile dysfunction option.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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