Drug interactions
Dronedarone + Lopinavir
Severity: Contraindicated
Dronedarone and Lopinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, which raises dronedarone levels. Lopinavir/ritonavir also prolongs QT and PR intervals, adding to arrhythmia risk.
What this interaction means in plain words
Dronedarone and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition reduces dronedarone clearance, with additive cardiac conduction effects.
What to do
Do not combine; use an alternative antiretroviral regimen or antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
Frequently asked questions
Can I take Dronedarone with Lopinavir?
MediHelp rates the interaction as contraindicated. Dronedarone and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, which raises dronedarone levels. Lopinavir/ritonavir also prolongs QT and PR intervals, adding to arrhythmia risk.
How serious is the interaction between Dronedarone and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiretroviral regimen or antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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