Drug interactions
Darifenacin + Loratadine
Severity: Minor
Darifenacin and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a moderate CYP2D6 inhibitor and a weak CYP3A4 inhibitor, so it may slightly raise loratadine levels. Both have anticholinergic activity, so additive dry mouth or constipation is possible.
What this interaction means in plain words
Darifenacin and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Loratadine belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4/CYP2D6 metabolism of loratadine, plus additive antimuscarinic effects.
What to do
No dose adjustment is required; monitor for anticholinergic effects such as dry mouth and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Loratadine?
MediHelp rates the interaction as minor. Darifenacin and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a moderate CYP2D6 inhibitor and a weak CYP3A4 inhibitor, so it may slightly raise loratadine levels. Both have anticholinergic activity, so additive dry mouth or constipation is possible.
How serious is the interaction between Darifenacin and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for anticholinergic effects such as dry mouth and constipation.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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