Drug interactions
Darifenacin + Methamphetamine
Severity: Minor
Darifenacin and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolised by CYP2D6, which darifenacin inhibits, so exposure may rise somewhat. The clinical effect is poorly characterised and likely small.
What this interaction means in plain words
Darifenacin and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Methamphetamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by darifenacin may reduce methamphetamine clearance.
What to do
Monitor heart rate, blood pressure and stimulant adverse effects when darifenacin is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Darifenacin with Methamphetamine?
MediHelp rates the interaction as minor. Darifenacin and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methamphetamine is partly metabolised by CYP2D6, which darifenacin inhibits, so exposure may rise somewhat. The clinical effect is poorly characterised and likely small.
How serious is the interaction between Darifenacin and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and stimulant adverse effects when darifenacin is started.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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