Drug interactions
Darifenacin + Nevirapine
Severity: Moderate
Darifenacin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower darifenacin concentrations. This can reduce control of overactive bladder symptoms.
What this interaction means in plain words
Darifenacin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing the first-pass and systemic metabolism of darifenacin.
What to do
Monitor for reduced symptom control and titrate darifenacin to effect within the labeled dose range. Consider an alternative agent if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Darifenacin with Nevirapine?
MediHelp rates the interaction as moderate. Darifenacin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower darifenacin concentrations. This can reduce control of overactive bladder symptoms.
How serious is the interaction between Darifenacin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and titrate darifenacin to effect within the labeled dose range. Consider an alternative agent if the response is inadequate.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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