Drug interactions
Darifenacin + Oxycodone
Severity: Minor
Darifenacin and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone is metabolized partly by CYP2D6 to oxymorphone, but CYP3A4 is the main pathway, so darifenacin has little clinical effect on its overall exposure. Both drugs slow gut and bladder function, so constipation and urinary retention can be additive.
What this interaction means in plain words
Darifenacin and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition may reduce formation of oxymorphone, and the two drugs have additive effects on smooth muscle.
What to do
No dose adjustment is needed. Monitor for constipation and urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Darifenacin with Oxycodone?
MediHelp rates the interaction as minor. Darifenacin and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxycodone is metabolized partly by CYP2D6 to oxymorphone, but CYP3A4 is the main pathway, so darifenacin has little clinical effect on its overall exposure. Both drugs slow gut and bladder function, so constipation and urinary retention can be additive.
How serious is the interaction between Darifenacin and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for constipation and urinary retention.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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