Drug interactions
Darifenacin + Ranolazine
Severity: Minor
Darifenacin and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a CYP3A4 substrate and darifenacin is not a significant CYP3A4 inhibitor, so a relevant pharmacokinetic rise is unlikely. Ranolazine also inhibits CYP2D6 and P-gp, which could modestly increase darifenacin levels.
What this interaction means in plain words
Darifenacin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Ranolazine belongs to Cardiovascular.
Why it happens
Possible modest CYP2D6 inhibition by ranolazine raising darifenacin; no important reverse effect.
What to do
No routine adjustment is needed; watch for anticholinergic effects and ECG changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Darifenacin with Ranolazine?
MediHelp rates the interaction as minor. Darifenacin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a CYP3A4 substrate and darifenacin is not a significant CYP3A4 inhibitor, so a relevant pharmacokinetic rise is unlikely. Ranolazine also inhibits CYP2D6 and P-gp, which could modestly increase darifenacin levels.
How serious is the interaction between Darifenacin and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for anticholinergic effects and ECG changes.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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