Drug interactions
Darifenacin + Trimipramine
Severity: Moderate
Darifenacin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine has strong anticholinergic properties, which add to darifenacin's muscarinic blockade and raise the risk of dry mouth, constipation, urinary retention and confusion. Darifenacin's CYP2D6 inhibition may also modestly raise trimipramine levels.
What this interaction means in plain words
Darifenacin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, plus possible CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic adverse effects and cardiac conduction changes; consider a less anticholinergic antidepressant in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Darifenacin with Trimipramine?
MediHelp rates the interaction as moderate. Darifenacin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine has strong anticholinergic properties, which add to darifenacin's muscarinic blockade and raise the risk of dry mouth, constipation, urinary retention and confusion. Darifenacin's CYP2D6 inhibition may also modestly raise trimipramine levels.
How serious is the interaction between Darifenacin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cardiac conduction changes; consider a less anticholinergic antidepressant in elderly patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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