Drug interactions
Darolutamide + Daunorubicin
Severity: Moderate
Darolutamide and Daunorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, and daunorubicin is a substrate of efflux transporters including BCRP. Higher daunorubicin exposure could worsen myelosuppression and cardiotoxicity, although the clinical significance is not well characterized.
What this interaction means in plain words
Darolutamide and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Daunorubicin belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux may increase daunorubicin exposure.
What to do
Monitor blood counts and cardiac function more closely. Consider daunorubicin dose adjustment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Daunorubicin?
MediHelp rates the interaction as moderate. Darolutamide and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, and daunorubicin is a substrate of efflux transporters including BCRP. Higher daunorubicin exposure could worsen myelosuppression and cardiotoxicity, although the clinical significance is not well characterized.
How serious is the interaction between Darolutamide and Daunorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function more closely. Consider daunorubicin dose adjustment if toxicity develops.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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