Drug interactions
Darolutamide + Imatinib
Severity: Moderate
Darolutamide and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, a transporter that limits the absorption and tissue penetration of imatinib. Imatinib exposure may therefore rise, increasing dose-related adverse effects such as edema, myelosuppression and hepatotoxicity.
What this interaction means in plain words
Darolutamide and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Darolutamide inhibits BCRP-mediated efflux of imatinib.
What to do
Monitor for imatinib adverse effects and blood counts, and consider an imatinib dose reduction if toxicity develops; measure trough levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darolutamide and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Imatinib?
MediHelp rates the interaction as moderate. Darolutamide and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, a transporter that limits the absorption and tissue penetration of imatinib. Imatinib exposure may therefore rise, increasing dose-related adverse effects such as edema, myelosuppression and hepatotoxicity.
How serious is the interaction between Darolutamide and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects and blood counts, and consider an imatinib dose reduction if toxicity develops; measure trough levels if available.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
