Drug interactions
Darolutamide + Lapatinib
Severity: Moderate
Darolutamide and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, a transporter that limits lapatinib absorption and contributes to its elimination. Lapatinib exposure may therefore increase, raising the chance of diarrhea, hepatotoxicity and QT prolongation.
What this interaction means in plain words
Darolutamide and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
BCRP inhibition by darolutamide increases lapatinib absorption and reduces its efflux.
What to do
Monitor for lapatinib adverse effects, including liver tests and ECG. Consider reducing the lapatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darolutamide and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Lapatinib?
MediHelp rates the interaction as moderate. Darolutamide and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, a transporter that limits lapatinib absorption and contributes to its elimination. Lapatinib exposure may therefore increase, raising the chance of diarrhea, hepatotoxicity and QT prolongation.
How serious is the interaction between Darolutamide and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib adverse effects, including liver tests and ECG. Consider reducing the lapatinib dose if toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
