Drug interactions
Darolutamide + Mitoxantrone
Severity: Moderate
Darolutamide and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is a BCRP substrate, and darolutamide inhibits BCRP. Higher mitoxantrone exposure may increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Darolutamide and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
Why it happens
Darolutamide inhibits BCRP-mediated efflux, which may increase mitoxantrone absorption and reduce its elimination.
What to do
Monitor blood counts and cardiac function (LVEF) closely. Consider reducing the mitoxantrone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Mitoxantrone?
MediHelp rates the interaction as moderate. Darolutamide and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitoxantrone is a BCRP substrate, and darolutamide inhibits BCRP. Higher mitoxantrone exposure may increase myelosuppression and cardiotoxicity.
How serious is the interaction between Darolutamide and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function (LVEF) closely. Consider reducing the mitoxantrone dose if toxicity appears.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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