Drug interactions
Darolutamide + Simvastatin
Severity: Moderate
Darolutamide and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, and simvastatin is a substrate of this transporter to some degree. Exposure may increase and raise the risk of myopathy.
What this interaction means in plain words
Darolutamide and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Darolutamide inhibits BCRP efflux, raising simvastatin systemic exposure.
What to do
Use the lowest effective simvastatin dose, and monitor for muscle pain or weakness, checking CK if symptoms arise. Consider switching to a statin less affected by BCRP.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Simvastatin?
MediHelp rates the interaction as moderate. Darolutamide and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, and simvastatin is a substrate of this transporter to some degree. Exposure may increase and raise the risk of myopathy.
How serious is the interaction between Darolutamide and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective simvastatin dose, and monitor for muscle pain or weakness, checking CK if symptoms arise. Consider switching to a statin less affected by BCRP.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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