Drug interactions
Darolutamide + Topotecan
Severity: Moderate
Darolutamide and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, a transporter of topotecan. Topotecan exposure may rise and increase hematologic toxicity.
What this interaction means in plain words
Darolutamide and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Topotecan belongs to Oncology.
Why it happens
Darolutamide inhibits BCRP-mediated efflux of topotecan.
What to do
Monitor blood counts closely if the combination is needed and consider reducing the topotecan dose if neutropenia worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Topotecan?
MediHelp rates the interaction as moderate. Darolutamide and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, a transporter of topotecan. Topotecan exposure may rise and increase hematologic toxicity.
How serious is the interaction between Darolutamide and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely if the combination is needed and consider reducing the topotecan dose if neutropenia worsens.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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