Drug interactions
Darunavir + Deflazacort
Severity: Major
Darunavir and Deflazacort: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and increases exposure to deflazacort's active metabolite. The risk of corticosteroid toxicity, including adrenal suppression and Cushing syndrome, is increased.
What this interaction means in plain words
Darunavir and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Deflazacort belongs to Miscellaneous.
Why it happens
Darunavir and its booster inhibit CYP3A4, reducing clearance of deflazacort's active metabolite.
What to do
Reduce the deflazacort dose to one-third of the usual dose and monitor for steroid adverse effects, or choose an alternative corticosteroid-sparing approach.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Deflazacort?
MediHelp rates the interaction as major. Darunavir and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and increases exposure to deflazacort's active metabolite. The risk of corticosteroid toxicity, including adrenal suppression and Cushing syndrome, is increased.
How serious is the interaction between Darunavir and Deflazacort?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to one-third of the usual dose and monitor for steroid adverse effects, or choose an alternative corticosteroid-sparing approach.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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