Drug interactions
Darunavir + Desogestrel-ethinyl estradiol
Severity: Moderate
Darunavir and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir regimens can change estrogen exposure, and ethinyl estradiol levels are often reduced. Contraceptive reliability may be compromised and hormone-related adverse effects may vary.
What this interaction means in plain words
Darunavir and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Ritonavir or cobicistat boosting with darunavir alters metabolism of ethinyl estradiol, with net induction of glucuronidation and oxidative pathways.
What to do
Recommend an alternative or additional non-hormonal contraceptive method while on darunavir. Review other contraceptive options with the patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Darunavir and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir regimens can change estrogen exposure, and ethinyl estradiol levels are often reduced. Contraceptive reliability may be compromised and hormone-related adverse effects may vary.
How serious is the interaction between Darunavir and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an alternative or additional non-hormonal contraceptive method while on darunavir. Review other contraceptive options with the patient.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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