Drug interactions
Darunavir + Desvenlafaxine
Severity: Minor
Darunavir and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, a minor clearance route for desvenlafaxine, so exposure may increase somewhat. Dose-related adverse effects may become more noticeable.
What this interaction means in plain words
Darunavir and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Desvenlafaxine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces the minor oxidative metabolism of desvenlafaxine.
What to do
No routine dose change is needed. Monitor blood pressure and tolerability and lower the desvenlafaxine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Desvenlafaxine?
MediHelp rates the interaction as minor. Darunavir and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, a minor clearance route for desvenlafaxine, so exposure may increase somewhat. Dose-related adverse effects may become more noticeable.
How serious is the interaction between Darunavir and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and tolerability and lower the desvenlafaxine dose if needed.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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