Drug interactions
Darunavir + Diazepam
Severity: Moderate
Darunavir and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and can raise diazepam concentrations. This may lead to excess sedation and respiratory depression.
What this interaction means in plain words
Darunavir and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Diazepam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 (and CYP2C19 by ritonavir) metabolism of diazepam, increasing exposure.
What to do
Monitor for sedation and reduce the diazepam dose if needed. Consider a benzodiazepine cleared by glucuronidation such as lorazepam as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Diazepam?
MediHelp rates the interaction as moderate. Darunavir and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and can raise diazepam concentrations. This may lead to excess sedation and respiratory depression.
How serious is the interaction between Darunavir and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduce the diazepam dose if needed. Consider a benzodiazepine cleared by glucuronidation such as lorazepam as an alternative.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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