Drug interactions
Darunavir + Didanosine
Severity: Moderate
Darunavir and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations raise gastric pH and may reduce absorption of some protease inhibitors, while didanosine must be taken on an empty stomach. Darunavir/ritonavir is taken with food, so timing conflicts may arise. Separating doses avoids the problem.
What this interaction means in plain words
Darunavir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Didanosine belongs to Anti Virals.
Why it happens
Different food requirements and pH-dependent absorption effects cause a timing interaction.
What to do
Give didanosine 1 hour before or 2 hours after darunavir/ritonavir. Monitor virologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Didanosine?
MediHelp rates the interaction as moderate. Darunavir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations raise gastric pH and may reduce absorption of some protease inhibitors, while didanosine must be taken on an empty stomach. Darunavir/ritonavir is taken with food, so timing conflicts may arise. Separating doses avoids the problem.
How serious is the interaction between Darunavir and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give didanosine 1 hour before or 2 hours after darunavir/ritonavir. Monitor virologic response.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Hydroxyurea. The full list is on the Didanosine page.
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