Drug interactions
Darunavir + Drospirenone
Severity: Moderate
Darunavir and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir- or cobicistat-boosted darunavir alters hormonal contraceptive exposure, and drospirenone levels may rise or the estrogen component may fall. This may reduce contraceptive reliability and raise hyperkalemia risk.
What this interaction means in plain words
Darunavir and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Drospirenone belongs to Endocrine.
Why it happens
Interference with CYP3A4 metabolism (inhibition and induction effects of boosted darunavir) altering hormone concentrations.
What to do
Use an alternative or additional non-hormonal contraceptive method. If used together, monitor serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Drospirenone?
MediHelp rates the interaction as moderate. Darunavir and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir- or cobicistat-boosted darunavir alters hormonal contraceptive exposure, and drospirenone levels may rise or the estrogen component may fall. This may reduce contraceptive reliability and raise hyperkalemia risk.
How serious is the interaction between Darunavir and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative or additional non-hormonal contraceptive method. If used together, monitor serum potassium.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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