Drug interactions
Darunavir + Fludrocortisone
Severity: Moderate
Darunavir and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, can increase fludrocortisone exposure and mineralocorticoid effects such as hypokalemia, edema and hypertension. Effects on darunavir from fludrocortisone are unlikely to be clinically important.
What this interaction means in plain words
Darunavir and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Fludrocortisone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by the boosted protease inhibitor reduces the metabolism of fludrocortisone.
What to do
Monitor blood pressure, serum potassium and fluid status, and reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fludrocortisone?
MediHelp rates the interaction as moderate. Darunavir and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, can increase fludrocortisone exposure and mineralocorticoid effects such as hypokalemia, edema and hypertension. Effects on darunavir from fludrocortisone are unlikely to be clinically important.
How serious is the interaction between Darunavir and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and fluid status, and reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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