Drug interactions
Darunavir + Fluvastatin
Severity: Minor
Darunavir and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin is metabolized mainly by CYP2C9, so boosted darunavir is expected to have a limited effect on its levels. A small increase in exposure is possible.
What this interaction means in plain words
Darunavir and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible minor effects on statin transport or metabolism; fluvastatin is primarily CYP2C9-metabolized.
What to do
Start with the lowest fluvastatin dose and titrate based on response. Counsel the patient to report muscle pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fluvastatin?
MediHelp rates the interaction as minor. Darunavir and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin is metabolized mainly by CYP2C9, so boosted darunavir is expected to have a limited effect on its levels. A small increase in exposure is possible.
How serious is the interaction between Darunavir and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest fluvastatin dose and titrate based on response. Counsel the patient to report muscle pain.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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