Drug interactions
Darunavir + Garlic
Severity: Moderate
Darunavir and Garlic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements have lowered exposure to some protease inhibitors, notably saquinavir. Data for darunavir are lacking, but a reduction in levels is possible and could risk loss of viral suppression.
What this interaction means in plain words
Darunavir and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Garlic belongs to Gastrointestinal Tract.
Why it happens
Possible induction of CYP3A4 or P-glycoprotein by garlic constituents; the mechanism is not established.
What to do
Avoid garlic supplements during darunavir therapy. Dietary garlic is generally acceptable, and viral load should be monitored if supplements are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Garlic?
MediHelp rates the interaction as moderate. Darunavir and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic supplements have lowered exposure to some protease inhibitors, notably saquinavir. Data for darunavir are lacking, but a reduction in levels is possible and could risk loss of viral suppression.
How serious is the interaction between Darunavir and Garlic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid garlic supplements during darunavir therapy. Dietary garlic is generally acceptable, and viral load should be monitored if supplements are used.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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