Drug interactions
Darunavir + Gliclazide
Severity: Moderate
Darunavir and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir may alter sulfonylurea exposure and protease inhibitors can cause insulin resistance and hyperglycemia. Glycemic control may therefore become less predictable.
What this interaction means in plain words
Darunavir and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Gliclazide belongs to Endocrine.
Why it happens
Ritonavir or cobicistat boosting alters CYP-mediated metabolism, while protease inhibitors can induce insulin resistance.
What to do
Monitor blood glucose frequently after starting darunavir and adjust gliclazide dose if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Gliclazide?
MediHelp rates the interaction as moderate. Darunavir and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir may alter sulfonylurea exposure and protease inhibitors can cause insulin resistance and hyperglycemia. Glycemic control may therefore become less predictable.
How serious is the interaction between Darunavir and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting darunavir and adjust gliclazide dose if control changes.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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