Drug interactions
Darunavir + Glipizide-metformin
Severity: Moderate
Darunavir and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce control with metformin and glipizide. Darunavir, usually boosted with ritonavir or cobicistat, may also alter glipizide exposure through CYP effects.
What this interaction means in plain words
Darunavir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Glipizide-metformin belongs to Endocrine.
Why it happens
Protease inhibitor-related insulin resistance opposes antidiabetic drugs, and boosted regimens can inhibit or induce enzymes involved in sulfonylurea metabolism.
What to do
Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen. Adjust antidiabetic doses as needed, watching for hypoglycemia with glipizide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Glipizide-metformin?
MediHelp rates the interaction as moderate. Darunavir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce control with metformin and glipizide. Darunavir, usually boosted with ritonavir or cobicistat, may also alter glipizide exposure through CYP effects.
How serious is the interaction between Darunavir and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen. Adjust antidiabetic doses as needed, watching for hypoglycemia with glipizide.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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