Drug interactions
Darunavir + Insulin degludec
Severity: Moderate
Darunavir and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, as a protease inhibitor, may cause insulin resistance and hyperglycemia, which can reduce the effect of insulin degludec. Glycemic control may deteriorate in diabetic patients.
What this interaction means in plain words
Darunavir and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Insulin degludec belongs to Endocrine.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake, opposing insulin action.
What to do
Monitor blood glucose and HbA1c after darunavir is started, and increase the insulin degludec dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Insulin degludec?
MediHelp rates the interaction as moderate. Darunavir and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, as a protease inhibitor, may cause insulin resistance and hyperglycemia, which can reduce the effect of insulin degludec. Glycemic control may deteriorate in diabetic patients.
How serious is the interaction between Darunavir and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after darunavir is started, and increase the insulin degludec dose if needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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