Drug interactions
Darunavir + Insulin glulisine
Severity: Moderate
Darunavir and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors including darunavir can cause insulin resistance and hyperglycemia, which may weaken the effect of insulin glulisine. Insulin requirements may increase.
What this interaction means in plain words
Darunavir and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Insulin glulisine belongs to Endocrine.
Why it happens
Protease inhibitors impair peripheral glucose uptake and insulin sensitivity.
What to do
Monitor blood glucose after starting darunavir and increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Insulin glulisine?
MediHelp rates the interaction as moderate. Darunavir and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors including darunavir can cause insulin resistance and hyperglycemia, which may weaken the effect of insulin glulisine. Insulin requirements may increase.
How serious is the interaction between Darunavir and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting darunavir and increase the insulin dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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