Drug interactions
Darunavir + Metformin-repaglinide
Severity: Moderate
Darunavir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise repaglinide levels, raising hypoglycemia risk. Protease inhibitors may also cause insulin resistance and hyperglycemia, which can reduce the effect of metformin.
What this interaction means in plain words
Darunavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
CYP3A4 inhibition (mainly from the boosting agent) raises repaglinide levels, and protease inhibitor-related insulin resistance opposes antidiabetic therapy.
What to do
Monitor blood glucose closely after starting or stopping darunavir and adjust the doses of the antidiabetic drugs as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Darunavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise repaglinide levels, raising hypoglycemia risk. Protease inhibitors may also cause insulin resistance and hyperglycemia, which can reduce the effect of metformin.
How serious is the interaction between Darunavir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting or stopping darunavir and adjust the doses of the antidiabetic drugs as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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