Drug interactions
Darunavir + Paroxetine
Severity: Moderate
Darunavir and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
When darunavir is boosted with ritonavir or cobicistat, paroxetine exposure may change; ritonavir-boosted regimens can reduce SSRI levels, whereas cobicistat can raise them. The antidepressant response may therefore be altered.
What this interaction means in plain words
Darunavir and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Paroxetine belongs to Central Nervous System.
Why it happens
Booster-dependent effects on paroxetine metabolism; the effect with darunavir alone is not clearly established.
What to do
Titrate paroxetine based on clinical response and tolerability. Monitor for loss of efficacy or increased adverse effects after changes in the antiretroviral regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Paroxetine?
MediHelp rates the interaction as moderate. Darunavir and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. When darunavir is boosted with ritonavir or cobicistat, paroxetine exposure may change; ritonavir-boosted regimens can reduce SSRI levels, whereas cobicistat can raise them. The antidepressant response may therefore be altered.
How serious is the interaction between Darunavir and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate paroxetine based on clinical response and tolerability. Monitor for loss of efficacy or increased adverse effects after changes in the antiretroviral regimen.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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