Drug interactions
Darunavir + Praziquantel
Severity: Moderate
Darunavir and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can increase praziquantel levels. This may amplify dizziness, drowsiness and gastrointestinal adverse effects.
What this interaction means in plain words
Darunavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Praziquantel belongs to Anti Parasitic.
Why it happens
Darunavir, particularly when boosted, inhibits CYP3A4-mediated metabolism of praziquantel.
What to do
Monitor for praziquantel toxicity and counsel patients about dizziness and sedation. No empiric dose change is generally needed for a short course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Praziquantel?
MediHelp rates the interaction as moderate. Darunavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can increase praziquantel levels. This may amplify dizziness, drowsiness and gastrointestinal adverse effects.
How serious is the interaction between Darunavir and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel toxicity and counsel patients about dizziness and sedation. No empiric dose change is generally needed for a short course.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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