Drug interactions
Darunavir + Prednisolone
Severity: Moderate
Darunavir and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and can raise prednisolone exposure modestly. Prolonged coadministration may increase corticosteroid adverse effects such as hyperglycemia and adrenal suppression.
What this interaction means in plain words
Darunavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Prednisolone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by darunavir (and its pharmacokinetic booster) reduces prednisolone metabolism.
What to do
Use the lowest effective prednisolone dose and monitor for Cushingoid effects and glucose changes with long-term use. Reduce the steroid dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Prednisolone?
MediHelp rates the interaction as moderate. Darunavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir inhibits CYP3A4 and can raise prednisolone exposure modestly. Prolonged coadministration may increase corticosteroid adverse effects such as hyperglycemia and adrenal suppression.
How serious is the interaction between Darunavir and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prednisolone dose and monitor for Cushingoid effects and glucose changes with long-term use. Reduce the steroid dose if toxicity appears.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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