Drug interactions
Dasatinib + Deferiprone
Severity: Major
Dasatinib and Deferiprone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia, and deferiprone also carries a risk of agranulocytosis. Combined use may produce additive bone marrow suppression and serious infection.
What this interaction means in plain words
Dasatinib and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Deferiprone belongs to Miscellaneous.
Why it happens
Additive myelosuppressive effects on neutrophil production.
What to do
Avoid the combination if possible; if both are needed, monitor absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Dasatinib with Deferiprone?
MediHelp rates the interaction as major. Dasatinib and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause neutropenia, and deferiprone also carries a risk of agranulocytosis. Combined use may produce additive bone marrow suppression and serious infection.
How serious is the interaction between Dasatinib and Deferiprone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if both are needed, monitor absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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