Drug interactions
Dasatinib + Desogestrel-ethinyl estradiol
Severity: Minor
Dasatinib and Desogestrel-ethinyl estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate and ethinyl estradiol is a weak CYP3A4 inhibitor, so a small rise in dasatinib exposure is conceivable. Clinical significance is likely modest. Dasatinib is also teratogenic, so reliable contraception remains important.
What this interaction means in plain words
Dasatinib and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may slightly reduce dasatinib metabolism.
What to do
Monitor for dasatinib toxicity such as myelosuppression and fluid retention; no empirical dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as minor. Dasatinib and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a CYP3A4 substrate and ethinyl estradiol is a weak CYP3A4 inhibitor, so a small rise in dasatinib exposure is conceivable. Clinical significance is likely modest. Dasatinib is also teratogenic, so reliable contraception remains important.
How serious is the interaction between Dasatinib and Desogestrel-ethinyl estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dasatinib toxicity such as myelosuppression and fluid retention; no empirical dose change is required.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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