Drug interactions
Dasatinib + Dexamethasone
Severity: Moderate
Dasatinib and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP3A4 and lower dasatinib exposure, which may reduce its antileukemic effect. Dasatinib is a weak CYP3A4 inhibitor and is unlikely to meaningfully increase dexamethasone levels.
What this interaction means in plain words
Dasatinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Dexamethasone belongs to Endocrine.
Why it happens
CYP3A4 induction by dexamethasone increases dasatinib metabolism.
What to do
Monitor hematologic and molecular response to dasatinib and consider dose adjustment if response is inadequate during prolonged dexamethasone use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Dexamethasone?
MediHelp rates the interaction as moderate. Dasatinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can induce CYP3A4 and lower dasatinib exposure, which may reduce its antileukemic effect. Dasatinib is a weak CYP3A4 inhibitor and is unlikely to meaningfully increase dexamethasone levels.
How serious is the interaction between Dasatinib and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic and molecular response to dasatinib and consider dose adjustment if response is inadequate during prolonged dexamethasone use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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