Drug interactions
Dasatinib + Diazepam
Severity: Minor
Dasatinib and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may modestly raise diazepam concentrations, but the clinical effect is expected to be small. Increased sedation is the possible consequence.
What this interaction means in plain words
Dasatinib and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Diazepam belongs to Musculoskeletal.
Why it happens
Dasatinib weakly inhibits CYP3A4, slightly reducing diazepam metabolism.
What to do
No dose change is usually needed; monitor for increased drowsiness. Reduce the diazepam dose if sedation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Diazepam?
MediHelp rates the interaction as minor. Dasatinib and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and may modestly raise diazepam concentrations, but the clinical effect is expected to be small. Increased sedation is the possible consequence.
How serious is the interaction between Dasatinib and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased drowsiness. Reduce the diazepam dose if sedation develops.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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