Drug interactions
Dasatinib + Didanosine
Severity: Moderate
Dasatinib and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on acidic gastric pH, and the buffering agents in didanosine formulations can reduce its absorption. This may lower dasatinib exposure and reduce efficacy.
What this interaction means in plain words
Dasatinib and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Didanosine belongs to Anti Virals.
Why it happens
Raised gastric pH from antacid buffers decreases solubility and absorption of dasatinib.
What to do
Use enteric-coated didanosine rather than buffered formulations where possible, or separate dosing, and monitor response to dasatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Didanosine?
MediHelp rates the interaction as moderate. Dasatinib and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib absorption depends on acidic gastric pH, and the buffering agents in didanosine formulations can reduce its absorption. This may lower dasatinib exposure and reduce efficacy.
How serious is the interaction between Dasatinib and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use enteric-coated didanosine rather than buffered formulations where possible, or separate dosing, and monitor response to dasatinib.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Hydroxyurea. The full list is on the Didanosine page.
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