Drug interactions
Dasatinib + Eribulin
Severity: Major
Dasatinib and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent use may raise the risk of serious ventricular arrhythmia. The risk is greater with hypokalemia, hypomagnesemia or underlying cardiac disease.
What this interaction means in plain words
Dasatinib and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Eribulin belongs to Oncology.
Why it happens
Additive QTc prolongation (pharmacodynamic).
What to do
Correct electrolyte abnormalities before starting, and monitor ECG periodically; consider an alternative if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Eribulin?
MediHelp rates the interaction as major. Dasatinib and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so concurrent use may raise the risk of serious ventricular arrhythmia. The risk is greater with hypokalemia, hypomagnesemia or underlying cardiac disease.
How serious is the interaction between Dasatinib and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte abnormalities before starting, and monitor ECG periodically; consider an alternative if QTc rises significantly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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