Drug interactions
Dasatinib + Erlotinib
Severity: Minor
Dasatinib and Erlotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib may modestly inhibit CYP3A4 and raise erlotinib exposure. Adverse effects such as rash and diarrhea could increase.
What this interaction means in plain words
Dasatinib and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Erlotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib reduces erlotinib metabolism.
What to do
Monitor for rash, diarrhea and other erlotinib toxicity, and reduce the erlotinib dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Dasatinib with Erlotinib?
MediHelp rates the interaction as minor. Dasatinib and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib may modestly inhibit CYP3A4 and raise erlotinib exposure. Adverse effects such as rash and diarrhea could increase.
How serious is the interaction between Dasatinib and Erlotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, diarrhea and other erlotinib toxicity, and reduce the erlotinib dose if needed.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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