Drug interactions
Dasatinib + Etrasimod
Severity: Major
Dasatinib and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is a sphingosine-1-phosphate receptor modulator that lowers circulating lymphocytes, and dasatinib is myelosuppressive and immunosuppressive. Their combined use has not been studied and may add to the risk of serious infection.
What this interaction means in plain words
Dasatinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression: lymphocyte sequestration by etrasimod plus myelosuppression from dasatinib.
What to do
Avoid combining the two, including during the weeks after etrasimod is stopped. If unavoidable, monitor blood counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Dasatinib with Etrasimod?
MediHelp rates the interaction as major. Dasatinib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is a sphingosine-1-phosphate receptor modulator that lowers circulating lymphocytes, and dasatinib is myelosuppressive and immunosuppressive. Their combined use has not been studied and may add to the risk of serious infection.
How serious is the interaction between Dasatinib and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two, including during the weeks after etrasimod is stopped. If unavoidable, monitor blood counts and watch for infection.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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